Asked by: Aid Bortz
asked in category: General Last Updated: 3rd March, 2020

Where do B cells bind to antigens?

B cells, unlike the other two classes of lymphocytes, T cells and natural killer cells, express B cell receptors (BCRs) on their cell membrane. BCRs allow the B cell to bind to a specific antigen, against which it will initiate an antibody response.

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In this regard, how do B cells bind to antigens?

Unlike T cells that recognize digested peptides, B cells recognize their cognate antigen in its native form. The B cell receptor used in recognition can also be secreted to bind to antigens and initiate multiple effector functions such as phagocytosis, complement activation, or neutralization of receptors.

One may also ask, what do B cell receptors bind to? Advances in Immunology Since the B cell receptor (BCR) is an immunoglobulin and readily binds soluble antigen in vitro it was long held that cognate antigen was acquired either in circulation or in the tissues.

Hereof, how does B cell get activated?

B-cells are activated by the binding of antigen to receptors on its cell surface which causes the cell to divide and proliferate. Some stimulated B-cells become plasma cells, which secrete antibodies. Others become long-lived memory B-cells which can be stimulated at a later time to differentiate into plasma cells.

Do B cells kill antigens directly?

Your body can then produce the most effective weapons against the invaders, which may be bacteria, viruses or parasites. Other types of T-cells recognise and kill virus-infected cells directly. Some help B-cells to make antibodies, which circulate and bind to antigens.

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