Asked by: Diyana Tropschuh
asked in category: General Last Updated: 17th May, 2020

What is Oxaloacetate used for?

Oxaloacetate is an intermediate of the citric acid cycle, where it reacts with acetyl-CoA to form citrate, catalyzed by citrate synthase. It is also involved in gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis. Oxaloacetate is also a potent inhibitor of complex II.

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Then, how is Oxaloacetate replenished?

Rather, oxaloacetate is formed by the carboxylation of pyruvate, in a reaction catalyzed by the biotin-dependent enzyme pyruvate carboxylase. If the energy charge is high, oxaloacetate is converted into glucose. If the energy charge is low, oxaloacetate replenishes the citric acid cycle.

Subsequently, question is, is Oxaloacetate consumed in the citric acid cycle? With each turn of the cycle one molecule of acetyl-CoA is consumed for every molecule of oxaloacetate present in the mitochondrial matrix, and is never regenerated. The three steps of beta-oxidation resemble the steps that occur in the production of oxaloacetate from succinate in the TCA cycle.

Similarly, you may ask, what foods contain Oxaloacetate?

Oxaloacetate is in every food you eat. It's in chicken, it's in peas, it's in potatoes, it's in apples, it's in spinach." And they said, "Well yes, but nobody has been selling food specifically for it's oxaloacetate content.

How does pyruvate become Oxaloacetate?

Pyruvate is first converted by pyruvate carboxylase to oxaloacetate (OAA) in the mitochondrion requiring hydrolysis of one molecule of ATP. However, during starvation when cytosolic NADH concentration is low and mitochrondrial NADH levels are high oxaloacetate can be used as a shuttle of reducing equivalents.

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