Asked by: Bakartxo Quagliarel
asked in category: General Last Updated: 11th April, 2020

What is N acetylcysteine mechanism of action in acetaminophen toxicity?

Abstract. N-Acetylcysteine is the drug of choice for the treatment of an acetaminophen overdose. It is thought to provide cysteine for glutathione synthesis and possibly to form an adduct directly with the toxic metabolite of acetaminophen, N-acetyl-p-benzoquinoneimine.

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Subsequently, one may also ask, how does N acetylcysteine work in acetaminophen overdose?

Acetylcysteine, also called N-acetylcysteine or NAC, works to reduce paracetamol toxicity by replenishing body stores of the antioxidant glutathione. Glutathione reacts with the toxic NAPQI metabolite so that it does not damage cells and can be safely excreted.

what are the side effects of N acetylcysteine? Common side effects of acetylcysteine solution include:

  • inflammation of the mouth,
  • nausea,
  • vomiting,
  • fever,
  • runny nose,
  • drowsiness,
  • clamminess,
  • chest tightness,

Consequently, what is the mechanism of action of acetylcysteine?

Mechanism of action/Effect: Acetylcysteine exerts its mucolytic action through its free sulfhydryl group, which opens the disulfide bonds and lowers mucus viscosity. This action increases with increasing pH and is most significant at pH 7 to 9.

What is the role of acetylcysteine?

When inhaled by mouth, acetylcysteine is used to help thin and loosen mucus in the airways due to certain lung diseases (such as emphysema, bronchitis, cystic fibrosis, pneumonia). This effect helps you to clear the mucus from your lungs so that you can breathe easier.

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