Asked by: Yusupha Rejonasked in category: General Last Updated: 5th February, 2020
WHAT IS A folate synthesis inhibitor?
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Moreover, what is folate synthesis?
All plants and fungi and certain protozoa, bacteria, and archaea can synthesize folate de novo through variations on the same biosynthetic pathway. The folate molecule is synthesized from pterin pyrophosphate and para-aminobenzoic acid through the action of dihydrofolate synthase.
Additionally, which drugs are classified as folate antagonists? A number of drugs such as aminopterin, methotrexate (amethopterin), pyrimethamine, trimethoprim and triamterene act as folate antagonists and produce folate deficiency by inhibiting this enzyme.
Also question is, what is a folic acid inhibitor?
folic acid antagonist (FOH-lik A-sid an-TA-guh-nist) A type of drug that stops cells from using folic acid to make DNA and may kill cancer cells. Certain folic acid antagonists are used to treat some types of cancer and inflammatory conditions, such as rheumatoid arthritis. Also called antifolate and folate antagonist.
How do sulfonamides inhibit folate synthesis?
Mechanism of Action Sulfonamides competitively inhibit the incorporation of PABA into folic acid, thereby preventing the synthesis of folic acid. Trimethoprim binds reversibly to and inhibits dihyrofolate reductase, an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, decreasing folic acid synthesis.