Asked by: Kanta Hoerner
asked in category: General Last Updated: 26th June, 2020

Is PNH an autoimmune disease?

In PNH there is a lack of certain proteins on the surface of the red blood cells. For a long time it has been believed that PNH should be considered an autoimmune disease for a different reason—because it occurs commonly in patients who have had aplastic anemia.

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In this manner, what are the symptoms of PNH?

Symptoms may include:

  • Abdominal pain.
  • Back pain.
  • Blood clots, may form in some people.
  • Dark urine, comes and goes.
  • Easy bruising or bleeding.
  • Headache.
  • Shortness of breath.
  • Weakness, fatigue.

Beside above, is there a cure for PNH? PNH is considered a chronic disease meaning that it lasts a long time. The only potential cure is a bone marrow transplant (BMT) . However, a BMT carries many risks and is not an option for many people. Other treatments are designed to ease symptoms and prevent problems.

Likewise, what medical condition is PNH?

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired, life-threatening disease of the blood. The disease is characterized by destruction of red blood cells (hemolytic anemia), blood clots (thrombosis), and impaired bone marrow function (not making enough of the three blood components).

What is the major cause of PNH?

Most likely, PNH arises in the setting of autoimmune bone marrow failure, as occurs in most cases of acquired aplastic anemia. Researchers believe that defective PNH stem cells survive the misguided attack by the immune system and multiply, while healthy stem cells are destroyed, resulting in the development of PNH.

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