Asked by: Adamina Gollasch
asked in category: General Last Updated: 26th February, 2020

How is a substrate and its enzyme like a lock and key?

The specific action of an enzyme with a single substrate can be explained using a Lock and Key analogy first postulated in 1894 by Emil Fischer. In this analogy, the lock is the enzyme and the key is the substrate. Only the correctly sized key (substrate) fits into the key hole (active site) of the lock (enzyme).

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Similarly, you may ask, what is the lock and key model for enzyme substrate interaction?

In lock-and-key model, the enzyme-substrate interaction suggests that the enzyme and the substrate possess specific complementary geometric shapes that fit exactly into one another. The lock and key model theory first postulated by Emil Fischer in 1894 shows the high specificity of enzymes.

Likewise, why are the active site and the substrates in an enzyme catalyzed often compared to a lock and key? The substrate that fits into its active site. Why are the active site and the substrates in an enzyme-catalyzed reaction often compared to a lock and key? They are complementary shapes and fit perfectly. Cells contain proteins that control enzyme activity during specific time periods.

In this manner, why does the lock and key analogy fit the linkage between an enzyme and its substrate?

The lock-and-key model portrays an enzyme as conformationally rigid and able to bond only to substrates that exactly fit the active site. The induced fit model portrays the enzyme structure as more flexible and is complementary to the substrate only after the substrate is bound.

What are 4 factors that can control or regulate enzyme activity?

Several factors affect the rate at which enzymatic reactions proceed - temperature, pH, enzyme concentration, substrate concentration, and the presence of any inhibitors or activators.

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