Asked by: Lacie Gontad
asked in category: General Last Updated: 21st February, 2020

Does Trazodone prevent dementia?

In vitro and animal studies have suggested that trazodone, a licensed antidepressant, may protect against dementia. However, no studies have been conducted to assess the effect of trazodone on dementia in humans.

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In this regard, is trazodone linked to dementia?

The association with dementia was greater with current use of trazodone than with past use, and short exposure to trazodone (<2 years) was found to be more strongly associated with dementia risk. "Our findings suggest that trazodone is unlikely to protect against dementia," Lau commented.

Furthermore, does Trazodone have anticholinergic effects? Trazodone is less potent but more selective than conventional tricyclic antidepressants; at low doses, trazodone acts as a serotonin antagonist, while at high doses it acts as a serotonin agonist. Trazodone causes significantly fewer anticholinergic side effects than does imipramine.

Additionally, can trazodone cause memory loss?

Trazodone produced small but significant impairments of short-term memory, verbal learning, equilibrium, and arm muscle endurance across time points. Although trazodone is efficacious for sleep maintenance difficulties, its associated cognitive and motor impairments may provide a modest caveat to healthcare providers.

What drugs are linked to dementia?

The researchers found that anticholinergic drugs in general were associated with a higher risk of dementia. More specifically, however, anticholinergic antidepressants, antipsychotic drugs, anti-Parkinson's drugs, bladder drugs, and epilepsy drugs were associated with the highest increase in risk.

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